Preclinical assessment of ulixertinib, a novel ERK1/2 inhibitor
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چکیده
منابع مشابه
Preclinical assessment of a novel small molecule inhibitor of indoleamine 2,3-dioxygenase 1 (IDO1)
Introduction iTeos leverages the science of the LICR to target the metabolism of the tumor microenvironment and develops small-molecule inhibitors. Tryptophan catabolism can suppress the anti-tumor immune response through expression of the rate-limiting enzyme IDO1. Local tryptophan reduction and metabolite production by the kynurenine pathway are associated with anergy/apoptosis of tumor-infil...
متن کاملPreclinical assessment of a novel small molecule inhibitor of tryptophan 2,3-dioxygenase 2 (TDO2)
Introduction iTeos leverages the science of LICR to target metabolism of the tumor microenvironment and develops small molecule immunomodulators. TDO2 is a heme-containing enzyme highly expressed in the liver, in specific brain regions and liver/brain tumors. It catalyses the first and rate-limiting step of tryptophan catabolism along the kynurenine pathway and thereby regulates systemic trypto...
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ژورنال
عنوان ژورنال: ADMET and DMPK
سال: 2017
ISSN: 1848-7718
DOI: 10.5599/admet.5.4.437